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教授

陈 祥
发布日期:2009-04-25浏览次数:字号:[ ]
 

1、个人简介

   陈祥,男,197810月生,博士,教授,博士生导师。哈佛大学医学院(HMS/BWH)访问学者。先后主持国家自然科学基金、国家重点研发计划课题、国家星火计划、中国科学院知识创新工程重要方向课题、江苏省自然科学基金、江苏省重点研发计划等。作为主要完成人先后参加国家973计划、国家863计划、国家科技重大传染病防治专项、国家畜禽产品质量安全风险评估专项、国家科技支撑计划、国家公益性行业(农业)科研专项、中央财政支持地方特色学科项目、教育部创新团队项目、农业部兽医卫生监督项目、江苏省自然科学基金(攀登计划)、江苏省高校自然科学基金重大项目、江苏省科技支撑计划、江苏高校优势学科建设工程项目、江苏省农业三新工程、江苏省农业科技自主创新项目等。发表学术论文100余篇,其中以第一或通讯作者发表论文60篇,授权国家发明专利10项,参编著作4部,已培养和联合培养博硕士生20余名。先后入选江苏青蓝工程优秀青年骨干教师、江苏“六大人才高峰”高层次人才等培养对象。曾获朱敬文特别奖、江苏省科技社团学会优秀青年人才、扬州大学校园先锋(科技先锋)新世纪人才工程优秀青年骨干教师最受学生欢迎的班主任优秀班主任优秀博士学位论文优秀毕业研究生研究生十大科技创新之星。现兼任江苏省人兽共患病学重点实验室第二届学术委员会秘书长,中国微生物学会人兽共患病病原学专业委员会委员,《中国人兽共患病学报》第七届编委,扬州市第八届政协委员等。

 E-mailchenxiang@yzu.edu.cn

 通讯地址:江苏省扬州市文汇东路48号扬州大学生物科学与技术学院6

 邮政编码:225009

2、主要研究方向

  人兽共患病与免疫学、食品安全与耐药性、生物制药(品)与体外诊断

3、实验室与平台

  江苏省人兽共患病学重点实验室

  江苏省动物重要疫病与人兽共患病防控协同创新中心

  教育部新型兽用疫苗工程研究中心

  教育部农业与农产品安全国际合作联合实验室

  农业部农产品质量安全生物性危害因子(动物源)控制重点实验室

 扬州大学测试中心食品中主要致病微生物检测室(国家资质认定单位)

4、在研科研项目

 (1)畜禽重要疫病病原学与流行病学研究,2017-2020,国家重点研发计划(2017YFD0500102),课题负责

 (2)畜禽重要胞内菌基因调控及其与宿主互作的分子机制研究,2017-2020,国家重点研发计划(2017YFD0500300),子课题负责

 (3)牛分枝杆菌RodA蛋白抑炎效应的分子机制,2017-2020,江苏省自然科学基金面上项目(BK20171285),负责

 (4)奶牛结核病、布病和沙门菌病新型诊断技术研发,2015-2018,江苏省重点研发计划(BE2015343),共同负责

5、承担的教学任务

  本科生教学:《生物制药(品)学》

  研究生教学:《生物制药工程》、《遗传学实验技术》

6、教学成果与学生工作

 江苏省研究生工作站负责人,指导学生获得国家级大学生创新创业训练计划项目江苏省高等学校大学生创新创业训练计划江苏省普通高校研究生科研创新计划等。指导的作品获2009年第十一届挑战杯全国大学生课外学术科技作品竞赛一等奖,2014年扬州大学第八届挑战杯竞赛二等奖。作为指导教师组成员,挑战传奇人兽共患病与食品安全科技创新团队荣获团中央2014年大学生小平科技创新团队

7、部分论文(论著)目录

 (1)Meng C, Wang XY, Xu ZZ, Hu MZ, Liu JY, Pan ZM, Chen X, Jiao XA. Murine Flt3 ligand-generated plasmacytoid and conventional dendritic cells display functional differentiation in activation, inflammation, and antigen presentation during BCG infection in Vitro. In Vitro Cell Dev Biol Anim, 2017, 53(1): 67-76

 (2)Guo R, Jiao Y, Li Z, Zhu S, Fei X, Geng S, Pan Z, Chen X, Li Q, Jiao X. Safety, protective immunity, and DIVA capability of a rough mutant Salmonella Pullorum vaccine candidate in broilers. Front Microbiol, 2017, 8: 547

 (3)Xie XL, Hu YC, Xu YH, Yin KQ, Li Y, Chen Y, Xia J, Xu LJ, Liu ZJ, Geng SZ, Li QC, Jiao XA, Chen X, Pan ZM. Genetic analysis of Salmonella enterica serovar Gallinarum biovar Pullorum based on characterization and evolution of CRISPR sequence. Veterinary Microbiology, 2017, 203: 81-87

 (4)Zhu LQ, Zhao XX, Yin Q, Liu XY, Chen X, Huang CJ, Suo X. Mucosal IgA and IFN-γ+CD8 T cell immunity are important in the efficacy of live Salmonella enteria serovar Choleraesuis vaccines. Sci Rep, 2017, 7: 46408

 (5)Xu ZZ, Chen X, Hu T, Meng C, Wang XB, Rao Y, Zhang XM, Yin YL, Pan ZM, Jiao XA. Evaluation of immunogenicity and protective efficacy elicited by Mycobacterium bovis BCG overexpressing Ag85A protein against Mycobacterium tuberculosis aerosol infection. Frontiers in Cellular and Infection Microbiology, 2016, 6: 3

 (6)Geng S, Tian Q, An S, Pan Z, Chen X, Jiao X. High-efficiency, two-step ccarless markerless genome genetic modification in Salmonella enterica, Curr Microbiol, 2016, 72(6): 700-706

 (7)Guo R, Geng S, Jiao H, Pan Z, Chen X, Jiao X. Evaluation of protective efficacy of a novel inactivated Salmonella Pullorum ghost vaccine against virulent challenge in chickens. Vet Immunol Immunopathol, 2016, 173: 27-33

 (8)Dai H, Xu ZZ, Wang M, Chen JH, Chen X, Pan ZM, Jiao XA. Development of a double-monoclonal antibody sandwich ELISA: Tool for chicken interferon-γ detection ex vivo. Can J Vet Res, 2016, 80(2): 134-140

 (9)Meng C, Wan T, Xu ZZ, Liu Y, Shan F, Sun L, Yin YL, Chen X, Jiao XA. Screening putative antigens as stimulators in the Mycobacterium bovis interferon-gamma release assay for cattle. Vet Immunol Immunopathol, 2015, 168(1-2): 111-117

 (10)Xu ZZ, Meng C, Qiang B, Gu HY, Sun L, Yin YL, Pan ZM, Chen X, Jiao XA. Differential effects of Mycobacterium bovis BCG on macrophages and dendritic cells from murine spleen.Int J Mol Sci, 2015, 16: 24127-24138

 (11)Chen X, Qin PY, Li J, Yang ZJ, Wen ZF, Jian ZQ, Zhao J, Hu XY, Jiao XA. Impedance immunosensor for bovine interleukin-4 using an electrode modified with reduced graphene oxide and chitosan. Microchimica Acta, 2015, 182(1-2): 369-376

 (12)Yang ZJ, Jian ZQ, Chen X, Li J, Qin PY, Zhao J, Jiao XA, Hu XY. Electrochemical impedance immunosensor for sub-picogram level detection of bovine interferon gamma based on cylinder-shaped TiO2 nanorods. Biosens Bioelectr, 2015, 63: 190-195

 (13)Yang JS, Zheng HC, Han SY, Jiang ZD, Chen X. The synthesis of nano-silver/sodium alginate composites and their antibacterial properties. RSC Advances, 2015, 5: 2378-2382

 (14)Xiong D, Song L, Jiao Y, Kang X, Chen X, Geng S, Pan Z, Jiao X. Mutational analysis identifies leucine-rich repeat insertions crucial for pigeon toll-like receptor 7 recognition and signaling. Vet Immunol Immunopathol. 2015, 168(1-2): 19-23

 (15)Chen X, Zhang WQ, Yin JJ, Zhang N, Geng SZ, Zhou XH,Wang YH, Gao S, Jiao XA. Escherichia coli isolates from sick chickens in China: Changes in antimicrobial resistance among 1993 and 2013. Vet J, 2014, 202(1): 112-115

 (16)Zhou X, Massol RH, Nakamura F, Chen X, Gewurz BE, Davis BM, Lencer WI, Waldor MK. Remodeling of the intestinal brush border underlies adhesion and virulence of an enteric pathogen. mBio, 2014, 5(4): e01639-14

 (17)Okada R, Zhou X, Hiyoshi H, Matsuda S, Chen X, Akeda Y, Kashimoto T, Davis BM, Iida T, Waldor MK, Kodama T. The Vibrio parahaemolyticus effector VopC mediates Cdc42 dependent invasion of cultured cells but is not required for pathogenicity in an animal model of infection. Cell Microbiol, 2014, 16(6): 938-947

 (18)Xu ZZ, Shan FL, Shan F, Meng C, Zhou XH, Zhang XM, Chen X, Jiao XA. Generation and application of a 293 cell line stably expressing bovine interferon-gamma. Prot Express Purif, 2014, 99: 131-137

 (19)Geng S, Jiao X, Barrow P, Pan Z, Chen X. Virulence determinants of Salmonella Gallinarum biovar Pullorum identified by PCR signature-tagged mutagenesis and the spiC mutant as a candidate live attenuated vaccine. Vet Microbiol, 2014, 168(2-4): 388-394

 (20)Chen X, Zhang WQ, Pan WJ, Yin JJ, Pan ZM, Gao S, Jiao XA. Prevalence of qnr, aac(6')-Ib-cr, qepA, and oqxAB in Escherichia coliisolates from humans, animals, and the environment. Antimicrob Agents Chemother, 2012, 56(6): 3423-3427

 (21)Zhang L, Pan ZM, Geng SZ, Chen X, Liu ZY, Zhao F, Jiao XA. A loop-mediated isothermal amplification method targets the HisJ gene for the detection of foodborne Salmonella. Euro Food Res Technol, 2012, 234(6): 1055-1062

 (22)Zhang L, Pan Z, Geng S, Chen X, Hu S, Liu H, Wu Y, Jiao X, Liu X. Sensitive, semi- nested RT-PCR amplification of fusion gene sequences for the rapid detection and differentiation of Newcastle disease virus. Res Vet Sci. 2010, 89(2): 282-289

 (23)Zhao LX, Chen X, Zhu XP, Yang WX, Dong LMi, Xu XJ, Gao S, Liu XF. Prevalence of virulence factors and antimicrobial resistance of uropathogenic Escherichia coli in Jiangsu province (China). Urology, 2009, 74(3): 702-707

 (24)Zhao LX, Chen X, Xu XJ, Gao S, Liu XF. Analysis of the AIDA-I gene sequence and prevalence in Escherichia coli isolates from pigs with post-weaning diarrhoea and oedema disease. Vet J, 2009, 180(1): 124-129

 (25)Pan ZM, Wang XQ, Zhang XM, Geng SZ, Chen X, Pan WJ, Cong QX, Liu XX, Jiao X, Liu X. Changes in antimicrobial resistance among Salmonella enterica subspecies enterica serovar Pullorum isolates in China from 1962 to 2007. Vet Microbiol, 2009, 136(3-4): 387-392

 (26)Geng SZ, Jiao XA, Pan ZM, Chen XJ, Zhang XM, Chen X. An improved method to knockout the asd gene of Salmonella enterica serovar Pullorum. J Biomed Biotechnol, 2009: 646380

 (27)Chen X, Gao S, Jiao XA, Liu XF. Prevalence of serogroups and virulence factors of Escherichia coli strains isolated from pigs with postweaning diarrhea in eastern China. Vet Microbiol, 2004, 103(1): 13-20

 (28)陈祥(参编). 国家十一五重点规划图书(食品和化妆品质量安全检测丛书)-食源性病原微生物检测指南,中国标准出版社,2010ISBN978-7-5066-5814-0

 (29)陈祥(参编). 兽医生物制品学(普通高等教育农业部十二五规划教材、全国高等农林院校十二五规划教材),第三版,中国农业出版社,2015ISBN978-7-109-20127-9

 (30)陈祥(参编). 沙门菌病(动物疫病防控出版工程),中国农业出版社,2015ISBN 978-7-109-20820-9

 (31)陈祥(参编). 人畜共患病(普通高等教育农业部“十二五”规划教材、全国高等农林院校“十二五”规划教材),第二版,中国农业出版社,2017ISBN978-7-109-23274-7

8、奖励

 (1)重要食源性人兽共患病原菌的传播生态规律及其防控技术. 2013年度教育部科学技术进步奖一等奖, 教育部(10/23, 2014

 (2)检测食品中沙门菌的环介导等温扩增方法及试剂盒. 第八届国际发明展览会发明创业奖·项目奖银奖, 中国发明协会(5/7, 2014

9、国家发明专利授权

 (1)新城疫病毒LAMP检测试剂盒及其检测方法。发明专利号ZL200710192278.32011

 (2)检测APECUPEC毒力基因表达水平的DNA芯片及其构建方法。发明专利号ZL200710023940.22012

 (3)检测食品中沙门菌的环介导等温扩增方法及试剂盒。发明专利号ZL201210003674.82013

 (4)分泌牛γ干扰素单克隆抗体的杂交瘤细胞株、其单克隆抗体及其应用。发明专利号ZL201210433949.12014

 (5)分泌牛IL-4单克隆抗体的杂交瘤细胞株、其单克隆抗体及其应用。发明专利号ZL201310405010.92015

 (6)一种针对结核病具有免疫原性的融合蛋白及其应用。发明专利号ZL201310113536X2015

 (7)Mb1961c蛋白的新用途。发明专利号ZL201410368059.62016

 (8)基于氧化锌纳米材料的牛伽马干扰素阻抗型免疫传感器的制备方法。发明专利号ZL20141034899842017

 (9)一种用于检测牛布鲁菌病的ELISPOT检测试剂盒。发明专利号ZL201610201618.32017

 (10)一种针对宫颈癌具有免疫原性的蛋白及其应用。发明专利号ZL20141066608762017

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